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Cas9 specifies functional viral targets during CRISPR-Cas adaptation

Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci and their associated (Cas) proteins provide adaptive immunity against viral infection in prokaryotes. Upon infection, short phage sequences known as spacers integrate between CRISPR repeats and are transcribed into small RNA gu...

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Bibliografische gegevens
Gepubliceerd in:Nature
Hoofdauteurs: Heler, Robert, Samai, Poulami, Modell, Joshua W., Weiner, Catherine, Goldberg, Gregory W., Bikard, David, Marraffini, Luciano A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385744/
https://ncbi.nlm.nih.gov/pubmed/25707807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14245
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