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CRISPR-Cas systems exploit viral DNA injection to establish and maintain adaptive immunity

CRISPR-Cas systems provide protection against viral(1) and plasmid(2) infection by capturing short DNA sequences from these invaders and integrating them into the CRISPR locus of the prokaryotic host(1). These sequences, known as spacers, are transcribed into short RNA guides(3–5) that specify the c...

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Detalles Bibliográficos
Publicado en:Nature
Main Authors: Modell, Joshua W., Jiang, Wenyan, Marraffini, Luciano A.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540373/
https://ncbi.nlm.nih.gov/pubmed/28355179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21719
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