Cas9 specifies functional viral targets during CRISPR-Cas adaptation

Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci and their associated (Cas) proteins provide adaptive immunity against viral infection in prokaryotes. Upon infection, short phage sequences known as spacers integrate between CRISPR repeats and are transcribed into small RNA gu...

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Foilsithe in:Nature
Main Authors: Heler, Robert, Samai, Poulami, Modell, Joshua W., Weiner, Catherine, Goldberg, Gregory W., Bikard, David, Marraffini, Luciano A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385744/
https://ncbi.nlm.nih.gov/pubmed/25707807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14245
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