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Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt)

Mitochondrial diseases and aging are associated with defects in the oxidative phosphorylation machinery (OXPHOS), which are the only complexes composed of proteins encoded by separate genomes. To better understand genome coordination and OXPHOS recovery during mitochondrial dysfunction, we examined...

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Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Nargund, Amrita M., Fiorese, Christopher J., Pellegrino, Mark W., Deng, Pan, Haynes, Cole M.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385436/
https://ncbi.nlm.nih.gov/pubmed/25773600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.02.008
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