Improvements in Radiographic Progression-Free Survival Stratified by ERG Gene Status in Castration-Resistant Prostate Cancer Patients Treated with Abiraterone

PURPOSE: Gene fusions leading to androgen receptor–modulated ERG overexpression occur in up to 70% of metastatic castration-resistant prostate cancers (mCRPC). We assessed the association between ERG rearrangement status and clinical benefit from abiraterone. EXPERIMENTAL DESIGN: COU-AA-302 is a pha...

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Publicat a:Clin Cancer Res
Autors principals: Attard, Gerhardt, de Bono, Johann S., Logothetis, Christopher J., Fizazi, Karim, Mukherjee, Som D., Joshua, Anthony M., Schrijvers, Dirk, van den Eertwegh, Alfons J.M., Li, Weimin, Molina, Arturo, Griffin, Thomas W., Kheoh, Thian, Ricci, Deborah S., Zelinsky, Kathy, Rathkopf, Dana E., Scher, Howard I., Ryan, Charles J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384987/
https://ncbi.nlm.nih.gov/pubmed/25593303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1961
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