A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores

Kinetochore (KT) localization of mitotic checkpoint proteins is essential for their function during mitosis. hSpindly KT localization is dependent on the RZZ complex and hSpindly recruits the dynein–dynactin complex to KTs during mitosis, but the mechanism of hSpindly KT recruitment is unknown. Thro...

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Bibliographic Details
Published in:J Cell Biol
Main Authors: Moudgil, Devinderjit K., Westcott, Nathan, Famulski, Jakub K., Patel, Kinjal, Macdonald, Dawn, Hang, Howard, Chan, Gordon K.T.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384735/
https://ncbi.nlm.nih.gov/pubmed/25825516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201412085
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