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Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia

Mutations in genes essential for protein homeostasis have been identified in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients. Why mature neurons should be particularly sensitive to such perturbations is unclear. We identified mutations in Rab8 in a genetic screen for e...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: West, Ryan J.H., Lu, Yubing, Marie, Bruno, Gao, Fen-Biao, Sweeney, Sean T.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384727/
https://ncbi.nlm.nih.gov/pubmed/25800055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201404066
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