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Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia

Mutations in genes essential for protein homeostasis have been identified in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients. Why mature neurons should be particularly sensitive to such perturbations is unclear. We identified mutations in Rab8 in a genetic screen for e...

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Detalles Bibliográficos
Publicado en:J Cell Biol
Autores principales: West, Ryan J.H., Lu, Yubing, Marie, Bruno, Gao, Fen-Biao, Sweeney, Sean T.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384727/
https://ncbi.nlm.nih.gov/pubmed/25800055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201404066
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