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MRK003, a Gamma Secretase Inhibitor exhibits promising in vitro pre-clinical activity in Multiple Myeloma and Non Hodgkin's Lymphoma

Notch stimulated signaling cascade results in transcriptional regulation of genes involved in cell fate decision, apoptosis and proliferation and has been implicated in various malignancies. Here, we investigated the impact of MRK003, an inhibitor of this pathway, on myeloma and lymphoma cells. We f...

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書誌詳細
出版年:Leukemia
主要な著者: Ramakrishnan, Vijay, Ansell, Stephen, Haug, Jessica, Grote, Deanna, Kimlinger, Teresa, Stenson, Mary, Timm, Michael, Wellik, Linda, Halling, Timothy, Rajkumar, S. Vincent, Kumar, Shaji
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384189/
https://ncbi.nlm.nih.gov/pubmed/21826062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.192
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