MRK003, a Gamma Secretase Inhibitor exhibits promising in vitro pre-clinical activity in Multiple Myeloma and Non Hodgkin's Lymphoma

Notch stimulated signaling cascade results in transcriptional regulation of genes involved in cell fate decision, apoptosis and proliferation and has been implicated in various malignancies. Here, we investigated the impact of MRK003, an inhibitor of this pathway, on myeloma and lymphoma cells. We f...

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Publicado en:Leukemia
Autores principales: Ramakrishnan, Vijay, Ansell, Stephen, Haug, Jessica, Grote, Deanna, Kimlinger, Teresa, Stenson, Mary, Timm, Michael, Wellik, Linda, Halling, Timothy, Rajkumar, S. Vincent, Kumar, Shaji
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384189/
https://ncbi.nlm.nih.gov/pubmed/21826062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.192
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