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Anti-Myeloma Activity of Akt Inhibition Is Linked to the Activation Status of PI3K/Akt and MEK/ERK Pathway

The PI3K/Akt/mTOR signal transduction pathway plays a central role in multiple myeloma (MM) disease progression and development of therapeutic resistance. mTORC1 inhibitors have shown limited efficacy in the clinic, largely attributed to the reactivation of Akt due to rapamycin induced mTORC2 activi...

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Detalhes bibliográficos
Main Authors: Ramakrishnan, Vijay, Kimlinger, Teresa, Haug, Jessica, Painuly, Utkarsh, Wellik, Linda, Halling, Timothy, Rajkumar, S. Vincent, Kumar, Shaji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503708/
https://ncbi.nlm.nih.gov/pubmed/23185517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050005
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