Anti-Myeloma Activity of Akt Inhibition Is Linked to the Activation Status of PI3K/Akt and MEK/ERK Pathway

The PI3K/Akt/mTOR signal transduction pathway plays a central role in multiple myeloma (MM) disease progression and development of therapeutic resistance. mTORC1 inhibitors have shown limited efficacy in the clinic, largely attributed to the reactivation of Akt due to rapamycin induced mTORC2 activi...

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Detaylı Bibliyografya
Asıl Yazarlar: Ramakrishnan, Vijay, Kimlinger, Teresa, Haug, Jessica, Painuly, Utkarsh, Wellik, Linda, Halling, Timothy, Rajkumar, S. Vincent, Kumar, Shaji
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503708/
https://ncbi.nlm.nih.gov/pubmed/23185517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050005
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