Multiple mechanisms contribute to the synergistic anti-myeloma activity of the pan-histone deacetylase inhibitor LBH589 and the rapalog RAD001

We examined the pre-clinical activity of pan- histone deacetylase inhibitor LBH589 in combination with mTORC1 inhibitor RAD001 and observed that the drug combination strongly synergized in inducing cytotoxicity in multiple myeloma (MM) cells. LBH589 caused an increase in acetylated histones and RAD0...

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Gepubliceerd in:Leuk Res
Hoofdauteurs: Ramakrishnan, Vijay, Kimlinger, Teresa, Timm, Michael, Haug, Jessica, Rajkumar, S. Vincent, Kumar, Shaji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645028/
https://ncbi.nlm.nih.gov/pubmed/25282334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2014.09.004
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