Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma

Bcl2 and IAP families are anti-apoptotic proteins deregulated in multiple myeloma (MM) cells. Pharmacological inhibition of each of these families has shown significant activity only in subgroups of MM patients. Here, we have examined a broad-spectrum Bcl2 family inhibitor Obatoclax (OBX) in combina...

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Vydáno v:Oncotarget
Hlavní autoři: Ramakrishnan, Vijay, Gomez, Marcus, Prasad, Vivek, Kimlinger, Teresa, Painuly, Utkarsh, Mukhopadhyay, Bedabrata, Haug, Jessica, Bi, Lintao, Rajkumar, S. Vincent, Kumar, Shaji
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302912/
https://ncbi.nlm.nih.gov/pubmed/27494845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11028
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