The SMAC mimetic LCL-161 selectively targets JAK2(V617F) mutant cells

BACKGROUND: Evasion from programmed cell death is a hallmark of cancer and can be achieved in cancer cells by overexpression of inhibitor of apoptosis proteins (IAPs). Second mitochondria-derived activator of caspases (SMAC) directly bind to IAPs and promote apoptosis; thus, SMAC mimetics have been...

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Bibliografiske detaljer
Udgivet i:Exp Hematol Oncol
Main Authors: Craver, Brianna M., Nguyen, Thanh Kim, Nguyen, Jenny, Nguyen, Hellen, Huynh, Christy, Morse, Sarah J., Fleischman, Angela G.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941266/
https://ncbi.nlm.nih.gov/pubmed/31908904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-019-0157-6
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