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The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma

Clinical observations suggest the existence of shared resistance pathways between rituximab and chemotherapy agents. To explore the mechanisms of rituximab resistance, our group created rituximab-resistant cell lines (RRCLs), which display altered expression of several inhibitor of apoptosis (IAP) f...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Runckel, Kyle, Barth, Matthew J., Mavis, Cory, Gu, Juan J., Hernandez-Ilizaliturri, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290104/
https://ncbi.nlm.nih.gov/pubmed/30530779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018018168
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