MRK003, a Gamma Secretase Inhibitor exhibits promising in vitro pre-clinical activity in Multiple Myeloma and Non Hodgkin's Lymphoma

Notch stimulated signaling cascade results in transcriptional regulation of genes involved in cell fate decision, apoptosis and proliferation and has been implicated in various malignancies. Here, we investigated the impact of MRK003, an inhibitor of this pathway, on myeloma and lymphoma cells. We f...

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Vydáno v:Leukemia
Hlavní autoři: Ramakrishnan, Vijay, Ansell, Stephen, Haug, Jessica, Grote, Deanna, Kimlinger, Teresa, Stenson, Mary, Timm, Michael, Wellik, Linda, Halling, Timothy, Rajkumar, S. Vincent, Kumar, Shaji
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384189/
https://ncbi.nlm.nih.gov/pubmed/21826062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.192
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