MRK003, a Gamma Secretase Inhibitor exhibits promising in vitro pre-clinical activity in Multiple Myeloma and Non Hodgkin's Lymphoma

Notch stimulated signaling cascade results in transcriptional regulation of genes involved in cell fate decision, apoptosis and proliferation and has been implicated in various malignancies. Here, we investigated the impact of MRK003, an inhibitor of this pathway, on myeloma and lymphoma cells. We f...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Ramakrishnan, Vijay, Ansell, Stephen, Haug, Jessica, Grote, Deanna, Kimlinger, Teresa, Stenson, Mary, Timm, Michael, Wellik, Linda, Halling, Timothy, Rajkumar, S. Vincent, Kumar, Shaji
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384189/
https://ncbi.nlm.nih.gov/pubmed/21826062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.192
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