Reactivation of latent HIV-1 by new semi-synthetic ingenol esters

The ability of HIV to establish long-lived latent infection is mainly due to transcriptional silencing of viral genome in resting memory T lymphocytes. Here, we show that new semi-synthetic ingenol esters reactivate latent HIV reservoirs. Amongst the tested compounds, 3-caproyl-ingenol (ING B) was m...

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Vydáno v:Virology
Hlavní autoři: José, Diego Pandeló, Bartholomeeusen, Koen, da Cunha, Rodrigo Delvecchio, Abreu, Celina Monteiro, Glinski, Jan, da Costa, Thais Barbizan Ferreira, Rabay, Ana Flávia Mello Bacchi, Filho, Luiz Francisco Pianowski, Dudycz, Lech W., Ranga, Udaykumar, Peterlin, Boris Matija, Pianowski, Luiz Francisco, Tanuri, Amilcar, Aguiar, Renato Santana
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383768/
https://ncbi.nlm.nih.gov/pubmed/25014309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.05.033
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