Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein

By phosphorylating elongation factors and the C-terminal domain of RNA polymerase II, the positive transcription elongation factor b (P-TEFb) is the critical kinase for transcription elongation and co-transcriptional processing of eukaryotic genes. It exists in inactive small nuclear ribonucleoprote...

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Hlavní autoři: Bartholomeeusen, Koen, Xiang, Yanhui, Fujinaga, Koh, Peterlin, B. Matija
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476326/
https://ncbi.nlm.nih.gov/pubmed/22952229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410746
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