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Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-Phase Arrest on Glioma Cell Lines

The identification of signaling pathways that are involved in gliomagenesis is crucial for targeted therapy design. In this study we assessed the biological and therapeutic effect of ingenol-3-dodecanoate (IngC) on glioma. IngC exhibited dose-time-dependent cytotoxic effects on large panel of glioma...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Silva, Viviane Aline Oliveira, Rosa, Marcela Nunes, Tansini, Aline, Martinho, Olga, Tanuri, Amilcar, Evangelista, Adriane Feijó, Cruvinel Carloni, Adriana, Lima, João Paulo, Pianowski, Luiz Francisco, Reis, Rui Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930609/
https://ncbi.nlm.nih.gov/pubmed/31771098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24234265
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