Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-Phase Arrest on Glioma Cell Lines

The identification of signaling pathways that are involved in gliomagenesis is crucial for targeted therapy design. In this study we assessed the biological and therapeutic effect of ingenol-3-dodecanoate (IngC) on glioma. IngC exhibited dose-time-dependent cytotoxic effects on large panel of glioma...

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Gepubliceerd in:Molecules
Hoofdauteurs: Silva, Viviane Aline Oliveira, Rosa, Marcela Nunes, Tansini, Aline, Martinho, Olga, Tanuri, Amilcar, Evangelista, Adriane Feijó, Cruvinel Carloni, Adriana, Lima, João Paulo, Pianowski, Luiz Francisco, Reis, Rui Manuel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930609/
https://ncbi.nlm.nih.gov/pubmed/31771098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24234265
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