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VARIABLE ACTIVE SITE LOOP CONFORMATIONS ACCOMMODATE THE BINDING OF MACROCYCLIC LARGAZOLE ANALOGUES TO HDAC8

The macrocyclic depsipeptide Largazole is a potent inhibitor of metal-dependent histone deacetylases (HDACs), some of which are drug targets for cancer chemotherapy. Indeed, Largazole partially resembles Romidepsin (FK228), a macrocyclic depsipeptide already approved for clinical use. Each inhibitor...

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Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: Decroos, Christophe, Clausen, Dane J., Haines, Brandon E., Wiest, Olaf, Williams, Robert M., Christianson, David W.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382410/
https://ncbi.nlm.nih.gov/pubmed/25793284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00010
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