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Biological Evaluation of New Largazole Analogues: Alteration of Macrocyclic Scaffold with Click Chemistry
[Image: see text] We report the design, synthesis, and biological evaluation of a new series of largazole analogues in which a 4-methylthiazoline moiety was replaced with a triazole and tetrazole ring, respectively. Compound 7 bearing a tetrazole ring was identified to show much better selectivity f...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American
Chemical Society
2012
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027506/ https://ncbi.nlm.nih.gov/pubmed/24900575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300371t |
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