TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy

Persistent HPV infection is recognized as the main etiologic factor for cervical cancer. HPV expresses the oncoproteins E6 and E7, both of which play key roles in maintaining viral infection and promoting carcinogenesis. While siRNA-mediated targeting of E6 and E7 transcripts temporarily induces apo...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Hu, Zheng, Ding, Wencheng, Zhu, Da, Yu, Lan, Jiang, Xiaohui, Wang, Xiaoli, Zhang, Changlin, Wang, Liming, Ji, Teng, Liu, Dan, He, Dan, Xia, Xi, Zhu, Tao, Wei, Juncheng, Wu, Peng, Wang, Changyu, Xi, Ling, Gao, Qinglei, Chen, Gang, Liu, Rong, Li, Kezhen, Li, Shuang, Wang, Shixuan, Zhou, Jianfeng, Ma, Ding, Wang, Hui
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382249/
https://ncbi.nlm.nih.gov/pubmed/25500889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78206
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