TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy

Persistent HPV infection is recognized as the main etiologic factor for cervical cancer. HPV expresses the oncoproteins E6 and E7, both of which play key roles in maintaining viral infection and promoting carcinogenesis. While siRNA-mediated targeting of E6 and E7 transcripts temporarily induces apo...

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Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Hu, Zheng, Ding, Wencheng, Zhu, Da, Yu, Lan, Jiang, Xiaohui, Wang, Xiaoli, Zhang, Changlin, Wang, Liming, Ji, Teng, Liu, Dan, He, Dan, Xia, Xi, Zhu, Tao, Wei, Juncheng, Wu, Peng, Wang, Changyu, Xi, Ling, Gao, Qinglei, Chen, Gang, Liu, Rong, Li, Kezhen, Li, Shuang, Wang, Shixuan, Zhou, Jianfeng, Ma, Ding, Wang, Hui
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2014
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382249/
https://ncbi.nlm.nih.gov/pubmed/25500889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78206
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