TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy

Persistent HPV infection is recognized as the main etiologic factor for cervical cancer. HPV expresses the oncoproteins E6 and E7, both of which play key roles in maintaining viral infection and promoting carcinogenesis. While siRNA-mediated targeting of E6 and E7 transcripts temporarily induces apo...

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Опубликовано в: :J Clin Invest
Главные авторы: Hu, Zheng, Ding, Wencheng, Zhu, Da, Yu, Lan, Jiang, Xiaohui, Wang, Xiaoli, Zhang, Changlin, Wang, Liming, Ji, Teng, Liu, Dan, He, Dan, Xia, Xi, Zhu, Tao, Wei, Juncheng, Wu, Peng, Wang, Changyu, Xi, Ling, Gao, Qinglei, Chen, Gang, Liu, Rong, Li, Kezhen, Li, Shuang, Wang, Shixuan, Zhou, Jianfeng, Ma, Ding, Wang, Hui
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2014
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382249/
https://ncbi.nlm.nih.gov/pubmed/25500889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78206
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