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TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy

Persistent HPV infection is recognized as the main etiologic factor for cervical cancer. HPV expresses the oncoproteins E6 and E7, both of which play key roles in maintaining viral infection and promoting carcinogenesis. While siRNA-mediated targeting of E6 and E7 transcripts temporarily induces apo...

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書誌詳細
出版年:J Clin Invest
主要な著者: Hu, Zheng, Ding, Wencheng, Zhu, Da, Yu, Lan, Jiang, Xiaohui, Wang, Xiaoli, Zhang, Changlin, Wang, Liming, Ji, Teng, Liu, Dan, He, Dan, Xia, Xi, Zhu, Tao, Wei, Juncheng, Wu, Peng, Wang, Changyu, Xi, Ling, Gao, Qinglei, Chen, Gang, Liu, Rong, Li, Kezhen, Li, Shuang, Wang, Shixuan, Zhou, Jianfeng, Ma, Ding, Wang, Hui
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2014
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382249/
https://ncbi.nlm.nih.gov/pubmed/25500889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78206
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