Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

MicroRNA-21 (miR-21) contributes to the pathogenesis of fibrogenic diseases in multiple organs, including the kidneys, potentially by silencing metabolic pathways that are critical for cellular ATP generation, ROS production, and inflammatory signaling. Here, we developed highly specific oligonucleo...

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Publicado en:J Clin Invest
Autores principales: Gomez, Ivan G., MacKenna, Deidre A., Johnson, Bryce G., Kaimal, Vivek, Roach, Allie M., Ren, Shuyu, Nakagawa, Naoki, Xin, Cuiyan, Newitt, Rick, Pandya, Shweta, Xia, Tai-He, Liu, Xueqing, Borza, Dorin-Bogdan, Grafals, Monica, Shankland, Stuart J., Himmelfarb, Jonathan, Portilla, Didier, Liu, Shiguang, Chau, B. Nelson, Duffield, Jeremy S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382246/
https://ncbi.nlm.nih.gov/pubmed/25415439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75852
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