Polysome shift assay for direct measurement of miRNA inhibition by anti-miRNA drugs

Anti-miRNA (anti-miR) oligonucleotide drugs are being developed to inhibit overactive miRNAs linked to disease. To help facilitate the transition from concept to clinic, new research tools are required. Here we report a novel method—miRNA Polysome Shift Assay (miPSA)—for direct measurement of miRNA...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Androsavich, John R., Sobczynski, Daniel J., Liu, Xueqing, Pandya, Shweta, Kaimal, Vivek, Owen, Tate, Liu, Kai, MacKenna, Deidre A., Chau, B. Nelson
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Methods Online
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737174/
https://ncbi.nlm.nih.gov/pubmed/26384419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv893
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