Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

MicroRNA-21 (miR-21) contributes to the pathogenesis of fibrogenic diseases in multiple organs, including the kidneys, potentially by silencing metabolic pathways that are critical for cellular ATP generation, ROS production, and inflammatory signaling. Here, we developed highly specific oligonucleo...

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發表在:J Clin Invest
Main Authors: Gomez, Ivan G., MacKenna, Deidre A., Johnson, Bryce G., Kaimal, Vivek, Roach, Allie M., Ren, Shuyu, Nakagawa, Naoki, Xin, Cuiyan, Newitt, Rick, Pandya, Shweta, Xia, Tai-He, Liu, Xueqing, Borza, Dorin-Bogdan, Grafals, Monica, Shankland, Stuart J., Himmelfarb, Jonathan, Portilla, Didier, Liu, Shiguang, Chau, B. Nelson, Duffield, Jeremy S.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382246/
https://ncbi.nlm.nih.gov/pubmed/25415439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75852
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