Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

MicroRNA-21 (miR-21) contributes to the pathogenesis of fibrogenic diseases in multiple organs, including the kidneys, potentially by silencing metabolic pathways that are critical for cellular ATP generation, ROS production, and inflammatory signaling. Here, we developed highly specific oligonucleo...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Gomez, Ivan G., MacKenna, Deidre A., Johnson, Bryce G., Kaimal, Vivek, Roach, Allie M., Ren, Shuyu, Nakagawa, Naoki, Xin, Cuiyan, Newitt, Rick, Pandya, Shweta, Xia, Tai-He, Liu, Xueqing, Borza, Dorin-Bogdan, Grafals, Monica, Shankland, Stuart J., Himmelfarb, Jonathan, Portilla, Didier, Liu, Shiguang, Chau, B. Nelson, Duffield, Jeremy S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382246/
https://ncbi.nlm.nih.gov/pubmed/25415439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75852
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