3D imaging of Sox2 enhancer clusters in embryonic stem cells

Combinatorial cis-regulatory networks encoded in animal genomes represent the foundational gene expression mechanism for directing cell-fate commitment and maintenance of cell identity by transcription factors (TFs). However, the 3D spatial organization of cis-elements and how such sub-nuclear struc...

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Bibliographic Details
Published in:eLife
Main Authors: Liu, Zhe, Legant, Wesley R, Chen, Bi-Chang, Li, Li, Grimm, Jonathan B, Lavis, Luke D, Betzig, Eric, Tjian, Robert
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2014
Subjects:
Biophysics and Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381973/
https://ncbi.nlm.nih.gov/pubmed/25537195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04236
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