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Real-time imaging of Huntingtin aggregates diverting target search and gene transcription

The presumptive altered dynamics of transient molecular interactions in vivo contributing to neurodegenerative diseases have remained elusive. Here, using single-molecule localization microscopy, we show that disease-inducing Huntingtin (mHtt) protein fragments display three distinct dynamic states...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Li, Li, Liu, Hui, Dong, Peng, Li, Dong, Legant, Wesley R, Grimm, Jonathan B, Lavis, Luke D, Betzig, Eric, Tjian, Robert, Liu, Zhe
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972539/
https://ncbi.nlm.nih.gov/pubmed/27484239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17056
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