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Real-time imaging of Huntingtin aggregates diverting target search and gene transcription
The presumptive altered dynamics of transient molecular interactions in vivo contributing to neurodegenerative diseases have remained elusive. Here, using single-molecule localization microscopy, we show that disease-inducing Huntingtin (mHtt) protein fragments display three distinct dynamic states...
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Publicado no: | eLife |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
eLife Sciences Publications, Ltd
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4972539/ https://ncbi.nlm.nih.gov/pubmed/27484239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17056 |
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