A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential

The Sox2 transcription factor must be robustly transcribed in embryonic stem (ES) cells to maintain pluripotency. Two gene-proximal enhancers, Sox2 regulatory region 1 (SRR1) and SRR2, display activity in reporter assays, but deleting SRR1 has no effect on pluripotency. We identified and functionall...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Zhou, Harry Y., Katsman, Yulia, Dhaliwal, Navroop K., Davidson, Scott, Macpherson, Neil N., Sakthidevi, Moorthy, Collura, Felicia, Mitchell, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265674/
https://ncbi.nlm.nih.gov/pubmed/25512558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.248526.114
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