Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease

Accumulation of N-terminal fragments of mutant huntingtin (mHTT) in the cytoplasm, nuclei and axons of neurons is a hallmark of Huntington's disease (HD), although how these fragments negatively impact neurons remains unclear. We followed the distribution of mHTT in the striata of transgenic R6...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Liu, Kuan-Yu, Shyu, Yu-Chiau, Barbaro, Brett A., Lin, Yuan-Ta, Chern, Yijuang, Thompson, Leslie Michels, James Shen, Che-Kun, Marsh, J. Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381756/
https://ncbi.nlm.nih.gov/pubmed/25398943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu574
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