The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade

Abstract Huntington disease is characterized by progressive neurodegeneration, especially of the striatum, and the presence of polyglutamine huntingtin (HTT) inclusions. Although HTT inclusions are most abundant in the neocortex, their neocortical distribution and density in relation to the extent o...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Richard A. Hickman, Phyllis L. Faust, Karen Marder, Ai Yamamoto, Jean-Paul Vonsattel
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Acta Neuropathologica Communications
Assuntos:
Huntington disease
HD
Huntingtin
Inclusion
Aggregation
Cortex
Acesso em linha:https://doi.org/10.1186/s40478-022-01364-1
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados