Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease

A means for measuring levels of soluble huntingtin proteins in clinical samples is essential for assessing the biological effects of potential mutant huntingtin (mtHtt) modifying treatments being developed for Huntington’s disease (HD). We have optimized a previously described cell-based Homogeneous...

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Detalhes bibliográficos
Main Authors: Moscovitch-Lopatin, Miriam, Weiss, Andreas, Rosas, Herminia Diana, Ritch, James, Doros, Gheorghe, Kegel, Kimberly B., Difiglia, Marian, Kuhn, Rainer, Bilbe, Graeme, Paganetti, Paolo, Hersch, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Huntington Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015780/
https://ncbi.nlm.nih.gov/pubmed/21278900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.RRN1205
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