Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease

A means for measuring levels of soluble huntingtin proteins in clinical samples is essential for assessing the biological effects of potential mutant huntingtin (mtHtt) modifying treatments being developed for Huntington’s disease (HD). We have optimized a previously described cell-based Homogeneous...

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Bibliographische Detailangaben
Hauptverfasser: Moscovitch-Lopatin, Miriam, Weiss, Andreas, Rosas, Herminia Diana, Ritch, James, Doros, Gheorghe, Kegel, Kimberly B., Difiglia, Marian, Kuhn, Rainer, Bilbe, Graeme, Paganetti, Paolo, Hersch, Steven
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Huntington Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015780/
https://ncbi.nlm.nih.gov/pubmed/21278900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.RRN1205
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