Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease

Adenosine monophosphate–activated protein kinase (AMPK) is a major energy sensor that maintains cellular energy homeostasis. Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of CAG repeats in the huntingtin (Htt) gene. In this paper, we report that activation of the...

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Detalhes bibliográficos
Main Authors: Ju, Tz-Chuen, Chen, Hui-Mei, Lin, Jiun-Tsai, Chang, Ching-Pang, Chang, Wei-Cheng, Kang, Jheng-Jie, Sun, Cheng-Pu, Tao, Mi-Hua, Tu, Pang-Hsien, Chang, Chen, Dickson, Dennis W., Chern, Yijuang
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144412/
https://ncbi.nlm.nih.gov/pubmed/21768291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201105010
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