A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration

Several human neurodegenerative disorders are characterized by the accumulation of 8-oxo-7,8-dihydroguanine (8-oxodG) in the DNA of affected neurons. This can occur either through direct oxidation of DNA guanine or via incorporation of the oxidized nucleotide during replication. Hydrolases that degr...

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Main Authors: De Luca, Gabriele, Russo, Maria Teresa, Degan, Paolo, Tiveron, Cecilia, Zijno, Andrea, Meccia, Ettore, Ventura, Ilenia, Mattei, Elisabetta, Nakabeppu, Yusaku, Crescenzi, Marco, Pepponi, Rita, Pèzzola, Antonella, Popoli, Patrizia, Bignami, Margherita
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580033/
https://ncbi.nlm.nih.gov/pubmed/19023407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000266
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