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hMTH1 expression protects mitochondria from Huntington's disease-like impairment
Huntington disease (HD) is a neurodegenerative disease caused by expansion of CAG repeats in the huntingtin (Htt) gene. The expression of hMTH1, the human hydrolase that degrades oxidized purine nucleoside triphosphates, grants protection in a chemical HD mouse model in which HD-like features are in...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Academic Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3507627/ https://ncbi.nlm.nih.gov/pubmed/22974734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.09.002 |
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