Adenosine A(2A) receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes

Niemann Pick type C (NPC) disease is a rare neurovisceral disorder. Mutations in npc1 gene induce an intracellular accumulation of unesterified cholesterol in the endosomal/lysosomal system causing cell death. We recently showed that stimulation of adenosine A(2A) receptors (A(2A)R) restores cholest...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: De Nuccio, Chiara, Bernardo, Antonietta, Ferrante, Antonella, Pepponi, Rita, Martire, Alberto, Falchi, Mario, Visentin, Sergio, Popoli, Patrizia, Minghetti, Luisa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611770/
https://ncbi.nlm.nih.gov/pubmed/31278313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46268-8
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg