hMTH1 expression protects mitochondria from Huntington's disease-like impairment

Huntington disease (HD) is a neurodegenerative disease caused by expansion of CAG repeats in the huntingtin (Htt) gene. The expression of hMTH1, the human hydrolase that degrades oxidized purine nucleoside triphosphates, grants protection in a chemical HD mouse model in which HD-like features are in...

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Main Authors: Ventura, Ilenia, Russo, Maria Teresa, De Nuccio, Chiara, De Luca, Gabriele, Degan, Paolo, Bernardo, Antonietta, Visentin, Sergio, Minghetti, Luisa, Bignami, Margherita
Formato: Artigo
Idioma:Inglês
Publicado: Academic Press 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507627/
https://ncbi.nlm.nih.gov/pubmed/22974734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.09.002
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