Regulation of Feedback between Protein Kinase A and the Proteasome System Worsens Huntington's Disease

Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a CAG repeat in the Huntingtin (HTT) gene. Abnormal regulation of the cyclic AMP (cAMP)/protein kinase A (PKA) pathway occurs during HD progression. Here we found that lower PKA activity was associated with prot...

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Detalhes bibliográficos
Main Authors: Lin, Jiun-Tsai, Chang, Wei-Cheng, Chen, Hui-Mei, Lai, Hsing-Lin, Chen, Chih-Yeh, Tao, Mi-Hua, Chern, Yijuang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623082/
https://ncbi.nlm.nih.gov/pubmed/23275441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01434-12
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