A New Drug Design Targeting the Adenosinergic System for Huntington's Disease

BACKGROUND: Huntington's disease (HD) is a neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. The expanded CAG repeats are translated into polyglutamine (polyQ), causing aberrant functions as well as aggregate formation of mutant Htt. Effective treat...

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Hlavní autoři: Huang, Nai-Kuei, Lin, Jung-Hsin, Lin, Jiun-Tsai, Lin, Chia-I, Liu, Eric Minwei, Lin, Chun-Jung, Chen, Wan-Ping, Shen, Yuh-Chiang, Chen, Hui-Mei, Chen, Jhih-Bin, Lai, Hsing-Lin, Yang, Chieh-Wen, Chiang, Ming-Chang, Wu, Yu-Shuo, Chang, Chen, Chen, Jiang-Fan, Fang, Jim-Min, Lin, Yun-Lian, Chern, Yijuang
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119665/
https://ncbi.nlm.nih.gov/pubmed/21713039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020934
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