Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins

Minichromosome maintenance (MCM) proteins are loaded onto chromatin during G1-phase and define potential locations of DNA replication initiation. MCM protein deficiency results in genome instability and high rates of cancer in mouse models. Here we develop a method of nascent strand capture and rele...

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Veröffentlicht in:Genome Res
Hauptverfasser: Kunnev, Dimiter, Freeland, Amy, Qin, Maochun, Leach, Robert W., Wang, Jianmin, Shenoy, Rajani M., Pruitt, Steven C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381527/
https://ncbi.nlm.nih.gov/pubmed/25762552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.176099.114
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