Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation

Ataxia-telangiectasia mutated (ATM) is needed for the initiation of the double-strand break (DSB) repair by homologous recombination (HR). ATM triggers DSB end resection by stimulating the nucleolytic activity of CtIP and MRE11 to generate 3′-ssDNA overhangs, followed by RPA loading and RAD51 nucleo...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Bakr, A., Oing, C., Köcher, S., Borgmann, K., Dornreiter, I., Petersen, C., Dikomey, E., Mansour, W.Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2015
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381069/
https://ncbi.nlm.nih.gov/pubmed/25753674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv160
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