Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis, and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induc...

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Bibliografske podrobnosti
izdano v:Nat Cell Biol
Main Authors: Mo, Jung-Soon, Meng, Zhipeng, Kim, Young Chul, Park, Hyun Woo, Hansen, Carsten Gram, Kim, Soohyun, Lim, Dae-Sik, Guan, Kun-Liang
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380774/
https://ncbi.nlm.nih.gov/pubmed/25751140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3111
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