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Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis, and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induc...
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| Publicado no: | Nat Cell Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4380774/ https://ncbi.nlm.nih.gov/pubmed/25751140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3111 |
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