Integration of Shallow Gradients of Shh and Netrin-1 Guides Commissural Axons

During nervous system development, gradients of Sonic Hedgehog (Shh) and Netrin-1 attract growth cones of commissural axons toward the floor plate of the embryonic spinal cord. Mice defective for either Shh or Netrin-1 signaling have commissural axon guidance defects, suggesting that both Shh and Ne...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Sloan, Tyler F. W., Qasaimeh, Mohammad A., Juncker, David, Yam, Patricia T., Charron, Frédéric
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380419/
https://ncbi.nlm.nih.gov/pubmed/25826604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002119
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