p130(CAS) Is Required for Netrin Signaling and Commissural Axon Guidance

Netrins are an important family of axon guidance cues. Here, we report that netrin-1 induces tyrosine phosphorylation of p130(CAS) (Crk-associated substrate). Our biochemical studies indicate that p130(CAS) is downstream of the Src family kinases and upstream of the small GTPase Rac1 and Cdc42. Inhi...

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Detalhes bibliográficos
Main Authors: Liu, Guofa, Li, Weiquan, Gao, Xue, Li, Xiaoling, Jürgensen, Claudia, Park, Hwan-Tae, Shin, Nah-Young, Yu, Jian, He, Ming-Liang, Hanks, Steven K., Wu, Jane Y., Guan, Kun-Liang, Rao, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014516/
https://ncbi.nlm.nih.gov/pubmed/17251438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4616-06.2007
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