Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma

BACKGROUND: Melanoma is the most fatal skin cancer displaying a high degree of molecular heterogeneity. Phenotype switching is a mechanism that contributes to melanoma heterogeneity by altering transcription profiles for the transition between states of proliferation/differentiation and invasion/ste...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Cheng, Phil F, Shakhova, Olga, Widmer, Daniel S, Eichhoff, Ossia M, Zingg, Daniel, Frommel, Sandra C, Belloni, Benedetta, Raaijmakers, Marieke IG, Goldinger, Simone M, Santoro, Raffaella, Hemmi, Silvio, Sommer, Lukas, Dummer, Reinhard, Levesque, Mitchell P
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378455/
https://ncbi.nlm.nih.gov/pubmed/25885555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0594-4
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