Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in Melanoma

Melanoma is the most fatal skin cancer, but the etiology of this devastating disease is still poorly understood. Recently, the transcription factor Sox10 has been shown to promote both melanoma initiation and progression. Reducing SOX10 expression levels in human melanoma cells and in a genetic mela...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Shakhova, Olga, Cheng, Phil, Mishra, Pravin J., Zingg, Daniel, Schaefer, Simon M., Debbache, Julien, Häusel, Jessica, Matter, Claudia, Guo, Theresa, Davis, Sean, Meltzer, Paul, Mihic-Probst, Daniela, Moch, Holger, Wegner, Michael, Merlino, Glenn, Levesque, Mitchell P., Dummer, Reinhard, Santoro, Raffaella, Cinelli, Paolo, Sommer, Lukas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309598/
https://ncbi.nlm.nih.gov/pubmed/25629959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004877
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