Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma

BACKGROUND: Melanoma is the most fatal skin cancer displaying a high degree of molecular heterogeneity. Phenotype switching is a mechanism that contributes to melanoma heterogeneity by altering transcription profiles for the transition between states of proliferation/differentiation and invasion/ste...

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Publicado en:Genome Biol
Autores principales: Cheng, Phil F, Shakhova, Olga, Widmer, Daniel S, Eichhoff, Ossia M, Zingg, Daniel, Frommel, Sandra C, Belloni, Benedetta, Raaijmakers, Marieke IG, Goldinger, Simone M, Santoro, Raffaella, Hemmi, Silvio, Sommer, Lukas, Dummer, Reinhard, Levesque, Mitchell P
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378455/
https://ncbi.nlm.nih.gov/pubmed/25885555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0594-4
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